WebAug 18, 2016 · The p53 tumor suppressor is a stress sensor, driving cell cycle arrest or apoptosis in response to DNA damage or oncogenic signals. p53 activation by oncogenic signals relies on the p19 (Arf) tumor suppressor, while p53 activation downstream of acute DNA damage is reported to be p19 (Arf)-independent. WebNIH3T3 cells, lacking the p19ARF locus, were used as a negative control. (G) Early-passage (P5) p53 null MEFs or 35-8cells were infected with retroviruses encoding c-Myc or E2F-1, or with an empty vector. Three days after selection, the expression levels of p19ARF forms were compared by Western blotting with p19ARF, Myc, E2F-1, and tubulin ...
E1A signaling to p53 involves the p19 ARF tumor suppressor
Webp14ARF (also called ARF tumor suppressor, ARF, p14ARF) is an a lternate r eading f rame protein product of the CDKN2A locus (i.e. INK4a / ARF locus). [1] p14ARF is induced in response to elevated mitogenic stimulation, such as aberrant growth signaling from MYC and Ras (protein). [2] Webp19(ARF) /p14(ARF) controls oncogenic functions of signal transducer and activator of transcription 3 in hepatocellular carcinoma These data show evidence that p19(ARF) /p14(ARF) determines the pro- or anti-oncogenic activity of U-Stat3 and pY-Stat3 in Ras-dependent HCC progression. termination of tenancy agreement singapore
The nucleolar SUMO‐specific protease SENP3 reverses …
WebJan 27, 2014 · Tumor suppressor protein p19 ARF (Arf; ... 22 Arf-induced SUMOylation is mediated by its ability to antagonize SENP3, ... GST-Arf (or control GST) and His-DDX5 were mixed and incubated for 30 min ... WebNov 1, 2004 · In turn, endogenous p19(Arf) and Senp3 are both destabilized in viable Npm-null mouse embryo fibroblasts (that also lack p53), and reintroduction of the human NPM protein into these cells reverses ... WebFeb 8, 2000 · Biochemical and functional analyses so far have indicated that p16 INK4A may act by regulating Rb, and p19 ARF by stabilizing and activating p53 through an interaction with the MDM2 protein 7,... tri cities churches