Irf2bp2 cancer
Web癌症免疫疗法是生物医学界目前最热门的领域之一。近日,发表在《科学》杂志上的一项研究中,科学家们发现了一种参与肿瘤免疫逃逸行为的关键蛋白,它与“赫赫有名”的PD-L1蛋白的表达密切相关。这一名为Cdk5的关键蛋白及其相关信号通路有望成为免疫疗法的新靶点。 WebMay 15, 2024 · Here, we identified a novel clinical variant, IRF2BP2 c.625_665del, from two members of a family with inflammatory conditions and investigated the function of IRF2BP2 and c.625_665del mutation in JAK–STAT pathway activation and inflammatory signaling. The levels of constitutive and cytokine-induced phosphorylation of STATs and total …
Irf2bp2 cancer
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WebMar 8, 2024 · Instituto Nacional do Câncer. Mar 2011 - Oct 20154 years 8 months. Rio de Janeiro Area, Brazil. - Planned and executed experiments to support the development of my thesis project about NFAT1 ... Web开馆时间:周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
WebJul 6, 2024 · We identified the immune modulator IRF2BP2 as a selective AML dependency. We validated AML cell dependency on IRF2BP2 with genetic and protein degradation … WebIRF2BP2 is involved in 1 fusion, with the following gene: CDX1 (1 mutation in 4 samples) Drug sensitivity data Mutations in IRF2BP2 are associated with altered sensitivity to the following 10 drugs: Dactolisib Docetaxel SN-38 Show all See all drug sensitivity data for IRF2BP2. External links
National Center for Biotechnology Information WebSep 20, 2024 · IRF2BP2 stabilized VGLL4 protein and repressed tumor progression via the inactivation of YAP-TEAD4 complex in liver cancer (41). In contrast, IRF2BP2 repressed …
WebApr 29, 2024 · The IRF2BP2 protein is found in different organisms and has been described as ubiquitously expressed in normal and tumor cells and tissues, indicating a possible role for this transcriptional...
WebApr 8, 2024 · The researchers discovered Richter syndrome-specific somatic driver mutations in genes including IRF2BP2, SRSF1, B2M, DNMT3A, and CCND3. They also found recurrent copy-number alterations beyond del(9p21)(CDKN2A/B), whole-genome duplication and chromothripsis, which they confirmed in 45 independent Richter syndrome cases and … reithoffer galleryWebSep 25, 2015 · In a recent issue of Circulation Research, Chen et al report that IRF 2–binding protein 2 (IRF2BP2) is a novel regulator of macrophage inflammation and lipid homeostasis that acts by maintaining anti-inflammatory transcription factor Krüppel-like factor 2 (KLF2) expression, therefore reducing susceptibility to atherosclerosis 6 ( Figure 2 ). reithoffer shows logoWebJul 29, 2024 · Program of Immunology and Tumor Biology, Brazilian National Cancer Institute (INCA), Rio de Janeiro, RJ, Brazil. 2. Division of Signaling and Gene Expression, La … reithoffer shows 2021WebJul 31, 2024 · Overall, cases 12 (harboring IRF2BP2-NTRK1 ), 13 ( PPL- NTRK1 ), and 25 ( ETV6-NTRK3) were morphologically similar, composed of lobules of partially fused papillae with scattered glomeruloid... reithoffer shows employmentWebExpression of IRF2BP2 (IRF-2BP2) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers. We use cookies to enhance the usability of … producers financial network colorado springsWebJun 15, 2024 · Recently, interferon regulatory protein 2 binding protein 2 ( IRF2BP2) emerged as a new RARA partner and was studied by next-generation RNA-sequencing analysis. IRF2BP2 has also been involved in other solid tumors [ 2, 3, 4 ]. Fig. 1 A Wright-Giemsa staining of abnormal promyelocytes at diagnosis. B Alpha naphthol acetate … producers firmWebCÁNCER DE PULMÓN El gen ALK (Anaplastic Lymphoma Kinase) y el gen EML4 (Echinoderm microtubule associated protein-like 4) se encuentran situados en el brazo corto del cromosoma 2, separados por 12 megabases de secuencia, y orientados en direcciones opuestas. Se ha descrito recientemente que alrededor del 5% de los carcinomas de … producers financial network