Web饶琳，孟飞龙，房冉，蔡晨依，赵小立. MicroRNA调控耳蜗毛细胞发育的分子机制. 饶琳，孟飞龙，房冉，蔡晨依，赵小立 WebThe ratio of cells expressing both F-actin and Brn3c in WT derivatives was around 52.5 ± 4.9%, while in BEM derivatives the ratio was dramatically reduced to 2.1 ± 0.5% (Figure 5E,I). Consistent with results above, FM1-43FX uptake studies demonstrated that the proportion of Myo7a-positive cells absorbing FM1-43FX meanwhile reached up to 51.1 ...
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WebThe mouse strain used for sequencing was C57BL/6J, which is the most widely used inbred strain. This strain is a permissive background for the expression of most mutations, but is resilient to many tumors. C57BL/6J mice are susceptible to atherosclerosis, type 2 diabetes and diet-induced obesity. WebMar 8, 2024 · Brn-3c Antibody (QQ8) is an IgG 1 κ mouse monoclonal Brn-3c antibody (also designated POU4F3 antibody) suitable for the detection of the Brn-3c protein of … randolph hames 1650
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Brn3c is a POU domain factor that is crucial for inner ear hair cell development. Targeted null Brn3c mutants have no mature hair cells [1, 2]. Close examination has revealed that some 'immature' hair cells form in Brn3c null mutants and express cellular markers such as Myosin VI and VIIa, calretinin and … See more Vestibular ganglia are smaller in Brn3c null mutants (Fig. 1b) than in control littermates (Fig. 1a), but larger than in BDNF or trkB null mutants of the same age [13, 15]. The reduction in apparent size of the vestibular … See more We processed four ears of P0 and P8 Brn3c null and control littermates for expression of BDNF and NT-3 using the riboprobes previously described [7]. We did not analyze neurotrophin expression in 6-month old animals … See more Reduction of vestibular innervation is more pronounced than at P0. Loss of afferents and, even more clearly of efferents, is most pronounced in … See more Very few fibers (both afferent and efferent) to the vestibular epithelia remain (Fig. 7a), thus displaying a further reduction of the pattern of innervation found in P8 Brn3c null mutants. Notably, there are still a number of fibers … See more WebThe middle image shows the diffuse expression of myosin VIIa (red)-positive cells and Brn3c (green; another inner ear hair cell marker)-positive cells. Co-expression of myosin VIIa and Brn3c was also observed. The right image shows the expression of FM1-43, which is a marker for mechanoelectrical transduction. WebBrn3a, Brn3b, Brn3c and β-actin transcripts were detected by RT-PCR. Total RNA was collected from wild-type (+/+) and Brn3b –/– retinas at E14.5 and E16.5. PCR products were visualized by ... randolph hall umw